"Pooling expertise and resources for the study of complex biological systems"
The Tennessee Mouse Genome Consortium (TMGC) involves several institutions and people from the state of Tennessee. A general operating model of the TMGC is to foster and sustain geographically-distributed collaborative projects. The TMGC is organized into several committees to assist in developing these collaborative projects. These collaborations should promote integrated research projects and promote the development of community research resources. These projects should pool existing TMGC expertise and resources for the study of complex biological systems, and in particular, promote mouse model systems as a biomedical and clinical research resource.
The TMGC institutions include a multipurpose National Laboratory with over 40 years of mouse genetics experience, several universities, and several medical research centers of sildenafil kamagra. This mix of different institutions brings a different range of expertise and resources to biomedical research projects and research training.
The TMGC consists of a wide variety of people from these institutions. These researchers and other staff have a wide variety of expertise that ranges from mouse genetics and phenotyping focused on neuroscience, aging, cardio- and renal-physiology, metabolism, and proteomics, basic biomedical research, clinical research, laboratory animal care, research administration, bioinformatics, and bioanalytical technologies.
This range of expertise and resources can allow for different--but collaborating--approaches that can advance the research and training in both the basic and clinical sciences.
This initiative was fostered by researchers in several institutions across the state of Tennessee. Discretionary funding provided by several institutions was instrumental in beginning the discussion, including a Laboratory Directors Research and Development Fund at ORNL and matching funding from Vanderbilt University, University of Tennessee (both Knoxville and Memphis), University of Memphis, St. Jude Children's Research Hospital and Meharry Medical College.
After several preliminary meetings, the first full organizational meeting was held at Vanderbilt University in June of 1998. Additional meetings were held to follow up on the large interest that this meeting helped foster across the state. The Memorandum of Cooperation officially beginning this Consortium was signed on Friday, December 4, 1998 at the Conference on the Impact of Emerging Technologies on Health Care in the 21st Century at the Hyatt in Knoxville.
The focus of the consortium is to become recognized and funded as a center for functional genomics and for developing mouse models of human genetic diseases.
The first scientific application from the TMGC was titled "TARGETED MUTAGENESIS OF MOUSE GENOME AND NEURAL PHENOTYPES" and submitted to the National Institutes of Health is response to RFA MH-99-007. This project was funded with Daniel Goldowitz as the principal investigator.
The involvement of the current member institutions will greatly augment our ability to identify both obvious and subtle whole-organism changes that result when mouse genes undergo mutation. Each institution can play a crucial role in screening the mutagenized mice for induced changes in diverse areas of behavior, physiology, development, biochemistry, and morphology.
The consortium is continuing to take advantage of expertise in mouse genetics, phenotyping, bioinformatics, basic biomedical research, and clinical research expertise across the state. It will be interested in discussions with researchers in the TMGC member institutions on submitting new grants as part of the consortium (please contact the TMGC administrators for more information about how to submit an TMGC grant).
Among the factors that have differentiated this Consortium from other efforts include the following: